Contractile Function in Hypertrophied Myocardium
نویسندگان
چکیده
منابع مشابه
Role of microtubules in the contractile dysfunction of hypertrophied myocardium.
OBJECTIVES We sought to determine whether the ameliorative effects of microtubule depolymerization on cellular contractile dysfunction in pressure overload cardiac hypertrophy apply at the tissue level. BACKGROUND A selective and persistent increase in microtubule density causes decreased contractile function of cardiocytes from cats with hypertrophy produced by chronic right ventricular (RV)...
متن کاملVolume overload influence on hypertrophied myocardium function.
The aim of this study was to demonstrate that hypertrophied cardiac muscle is more sensitive to volume-overload than normal cardiac muscle. We assessed the mechanical function of isolated left ventricular papillary muscle from male spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) submitted to volume overload caused by aortocaval fistula (ACF) for 30 day...
متن کاملProteasome inhibition in hypertrophied myocardium.
CARDIAC REMODELING has been described as both an adaptive and a maladaptive process. The adaptive component enables the heart to maintain function in response to pressure overload and has the effect of decreasing ventricular wall stress and compensates for the increased workload preserving cardiac function. Along with the changes in ventricular mechanics, the development of hypertrophy is accom...
متن کاملCellular versus myocardial basis for the contractile dysfunction of hypertrophied myocardium.
Contractile dysfunction has been demonstrated in many previous studies of experimental right ventricular pressure-overload hypertrophy; however, given the complex changes that occur both in the cardiac muscle cell and in the multiple components of the cardiac interstitium, it is not clear whether the contractile dysfunction observed is an intrinsic property of the cardiac muscle cell or whether...
متن کاملThe effect of chronic digitoxin administration on the contractile state of normal and nonfailing hypertrophied myocardium.
To determine the effect of prolonged digitoxin administration on contractile function of nonfailing myocardium, right ventricular papillary muscle mechanics were examined after 6 or 24 wk of glycoside administration to control and pulmonary artery banded cats. Resting length-tension relations were not affected by digitoxin; however, isometrically developed force and the maximal rate of force de...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Age and Ageing
سال: 1997
ISSN: 0002-0729,1468-2834
DOI: 10.1093/ageing/26.suppl_1.p4-b